NCMP-04. COMBINATION BRAF/MEK INHIBITION IMPROVES SURVIVAL WITH LEPTOMENINGEAL DISEASE FROM MELANOMA IN A SINGLE INSTITUTIONAL REVIEW AT MOFFITT CANCER CENTER

نویسندگان

چکیده

Abstract Melanoma is third most common cancer to metastasize the leptomeningeal space and confers a dismal prognosis. We retrospectively identified 87 cases of melanoma related disease (M-LMD) diagnosed between 2011-2020 at Moffitt Cancer Center. The average age diagnosis was 54 years (range 28-93 years) with male predominance (50 men vs 36 women). There significant increase in median overall survival (OS) for patients BRAF V600E mutation, but only if they were treated combined BRAF/MEK inhibitors after LMD (5.54 months 1.39 months; p < 0.01). Immune checkpoint also associated small OS when given M-LMD (2.73 1.38mths; no association gender (p > 0.05). current data supports use treatment mutated M-LMD. More work needed improve these without targetable mutation

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ژورنال

عنوان ژورنال: Neuro-oncology

سال: 2022

ISSN: ['1523-5866', '1522-8517']

DOI: https://doi.org/10.1093/neuonc/noac209.732